0次浏览 发布时间：2025-04-03 22:25:00
Recently, a Chinese research team published a paper in "Nature", reporting the world's first successful case of transplanting gene-modified pig liver into a brain-dead human recipient. The transplanted liver demonstrated normal physiological function, marking a significant step toward the clinical application of animal-to-human organ transplantation.
Dou Kefeng, an academician at the Chinese Academy of Sciences (CAS), led the study. His team used a pig with six gene edits as the donor, transplanting its liver into a brain-dead patient who maintained basic bodily functions. At the same time, the patient's original liver was retained to simulate support therapy for patients with clinical liver failure. "Nature" described this research as a"milestone" in the transplantationof animal organs into humans.
In recent years, xenotransplantation using gene-modified pigs as organ donors has made remarkable progress. Lai Yiwei, a researcherof BGl Research, noted that in 2022, the University of Maryland School of Medicine transplanted genetically modified pig hearts into two human patients, prolonging survival by approximately two months and 40 days, respectively. Meanwhile, China's Xijing Hospital also successfully performed a pig kidney transplant with polygenic editing, with the organ functioning in the recipient for at least 13 days. Lai pointed out that while gene editing has mitigated hyperacute rejection, challenges in long-term immunologic tolerance remain unresolved, and the long-term stability of xenografts requires further validation.
China is now at the forefront of global xenotransplantation research. Lai emphasized that Chinese research teams and clinical experts have accumulated extensive expertise, and the country's industrialization process is also advancing rapidly. Companies such as Clonorgan and Qihan Biotech are actively developing genetically modified pig organ donors with low immunologic rejection," he noted. He believes that China is not only keeping pace with international research but is also leading in industrialization, providing crucial support for further breakthroughs in xenotransplantation technology.
Source: Lingnan on the Cloud
中国科学家创造动物器官人类移植里程碑
近日，中国研究团队在英国《自然》杂志在线发表论文，报告了世界首例基因编辑猪肝移植至脑死亡人体内的成功案例。移植肝脏生理功能表现良好，标志着动物器官移植向临床应用迈出了重要一步。
此次研究由中国科学院院士窦科峰团队完成。他们以一只经过6处基因编辑的猪为供体，将其肝脏移植至一名脑死亡但仍维持基本机能的患者体内，同时保留患者自身肝脏，以模拟临床肝衰竭患者的替代治疗。《自然》杂志在相关新闻中称这一研究是“动物器官移植给人的一个里程碑”。
近年来，基因编辑猪作为供体的异种器官移植取得显著进展。华大生命科学研究院主任科学家赖毅维介绍，2022年，马里兰大学医学院曾将基因编辑猪心脏移植至两名患者体内，分别延长生命约两个月和40天；中国西京医院也成功进行了多基因编辑猪肾移植，器官在受体体内工作至少13天。赖毅维指出，尽管基因编辑技术减少了超急性排斥反应，但长期免疫耐受问题仍未解决，异种器官在长期维持中的稳定性也有待进一步验证。
在全球异种移植研究中，中国已处于国际前沿。赖毅维表示，国内科研团队与临床专家积累深厚，产业化进程也处于领先水平。“如中科奥格、启函生物等企业正致力于基因编辑和低免疫排斥猪器官供体的研发。”他认为，中国不仅在科研层面紧跟国际步伐，在产业化推进上也走在前列，为异种移植技术的进一步突破提供了支撑。
文丨记者 林园
译丨柯妃娟
英文审校丨王枥焓
